A Concept Suggestion on the Effect of Cigarette Smoking in Inflammatory Destruction of Gingiva

Noushin Jalayer Naderi

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=116640
Date :  2019/05/26
Publish in :    Iranian Journal of Pathology


Keywords :Gingiva

Abstract :

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Cigarette smoking has destructive effect on periodontal tissue. The rates of loss o f periodontal attachment and recession of gingival are higher in smokers than non - smokers (1 - 2). Previous studies on the inflammatory immune responses in smokers’ periodontitis have mainly focused on the role of neutrophils. Tumor necrosis factor – α, prosta glandin E2 and matrix metalloproteinase - 8 have been shown to rise in smokers with periodontitis (3 - 4). Different functions of mast cells and eosinophils in inflammatory immune responses make them distinctive cells in disease pathogenesis (5 - 6). In an inve stigation, our team examined the effect of smoking on mast cells density in chronic periodontitis. The study showed that the mean number of mast cells in smokers was significantly lower compared to the non - smokers . Based on the literature , no research was found regarding the effect of cigarette smoking on eosinophil cells in human periodontitis. Eosinophils and mast cells regulate the hypersensitivity reactions by affecting each other function (5). Thus, in the next study, we examined this issue on the same samples. The results revealed that the number of eosinophil count in smokers was significantly lower than non - smokers.