Effect of aqua extract Zataria multiflura and Zns nanoparticle on Tachyzoites of Toxoplasma in Balb/C mice

Fariba Khoshzaban | Ali Salimzade

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=116810
Date :  2019/08/27
Publish in :    20th Iranian International Congress of Microbiology

Link :  http://ismc.kmu.ac.ir/files_site/files/r_19_190902193323.pdf
Keywords :

Abstract :

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Introduction and Objectives: Toxoplasma gondii is one the most important apicomplexan parasite of humans and other warm-blooded animals. We have studied the effect of aqua extract Zataria multiflura on tachyzoite of Toxoplasma gondii in male Balb/C mice. Materials and Methods: A total of 20 Balb/C mice (control& experiment) were included, and 10000 Toxoplasma organisms of the RH strain Toxoplasma gondii were given oral to each mouse. Zataria multiflura extract was administered in 4 groups (control, ZM100, ZM500, NZM100 and NZM500). All of the experimental mice except control group were given extract oral (with or without nanoparticles) with 100or 500 mg/kg/day doses 3houres after infection and they received for 7-day single dose per day. Results: One hundred percent of mice were survived with all of used doses of Zataria multiflura extract with or without nanoparticles at 5 days after infection but one hundred percent of positive control mice were died P=0.015. Comparing of groups, tachyzoites of toxoplasma in the spleen were disappeared in ZM100 (60) group and in NZM100 (40) group (P=0.000) Conclusion: The results demonstrate that Zataria multiflura extract are effective on tachyzoites of toxoplasma in mice. Tachyzoites of toxoplasma in the brain of mice were disappeared.

http://ismc.kmu.ac.ir/files_site/files/r_19_190902193323.pdf