Shahed University

Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure

Roya Yaraee Shahmirzady | Shams Jalaaldin | Faramarz Fallahiarezoudar | Shamsa Shariatpanahi | Mohammad Ali Javadi | Mahmoud Mahmoudi | Mohamad Reza Sedighi Moghadam | Raheleh Shakeri | Mohammad Mehdi Naghizadeh | Tooba Ghazanfari | Hassan Ghasemi | Fatemeh Heidary | Kaboudanian Ardestani

URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=116973
Date :  2019/10/13
Publish in :    International Immunopharmacology
DOI :  https://doi.org/10.1016/j.intimp.2019.105820
Link :  http://dx.doi.org/10.1016/j.intimp.2019.105820
Keywords :E-selectin; Intercellular adhesion molecule 1 (ICAM-1); L-selectin; Ocular injury; P-selectin; Sulfur mustard

Abstract :
INTRODUCTION: In this study, the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), P-, E-, and L-selectins were investigated in seriously eye-injured patients exposed to sulfur mustard (SM). MATERIAL AND METHODS: A total of 128 individuals with SM-induced serious eye injuries and 31 healthy male controls were included in this study. The serum concentration of soluble forms of adhesion molecules was measured by enzyme-linked immunosorbent assay (ELISA) method. RESULT: The serum level of soluble ICAM-1 was significantly higher in the SM-exposed individuals with an abnormality in tear meniscus height, corneal verticillata, and pannus compared with SM-exposed individuals without these abnormalities. There were no significant differences in the level of all three measured selectins between the SM-exposed group and the control groups. SM-exposed individuals with corneal defect had a significantly higher level of soluble E-selectin than SM-exposed individuals without this abnormality. The serum level of soluble P-selectin in the SM-exposed group with limbal abnormality was significantly lower than that in the SM-exposed without this abnormality; also it was significantly higher in SM-exposed group with fundus abnormality compared to that in the control group or SM-exposed group without this abnormality. CONCLUSION: The changes in the levels of selectins and ICAM-1 in the SM-exposed group with various ocular abnormalities is a defense mechanism against the toxicity of SM. Further analysis is required to understand the molecular mechanisms of the relationship between adhesion molecules with ocular complications in SM-exposed individuals.