Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure

Tooba Ghazanfari | Ali Mostafaie | Farideh talebi | Mohammad Reza Vaez Mahdavi | Mohammad Ebrahim Yarmohammadi | Nayere Askari | Sakine Moaiedmohseni | Ali Mohammad Mohseni Majd | Ensie Sadat Mirsharif | Zeinab Ghazanfari | Zuhair Mohammad Hassan | Davoud Jamali | Soghrat Faghihzadeh | Jalaledin Shams

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137441
Date :  2020/02/01
Publish in :    International Immunopharmacology
DOI :  https://doi.org/10.1016/j.intimp.2019.105895
Link :  http://dx.doi.org/10.1016/j.intimp.2019.105895
Keywords :Sulfur mustard Ocular abnormality Immunoglobulin

Abstract :

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Sulfur mustard (SM) is a potent toxic agent that cause local and systemic changes in the human body such as dysregulation of the immunological system. This gas affects different organs such as lungs, skin, eyes and the gastrointestinal tract. Methods: 128 veterans with SM-induced eye injuries were examined and compared to 31 gender- and agematched healthy controls. Serum levels of IgM, IgE, IgA, IgG, and IgG subclasses were measured using ELISA method. Results: There was no significant difference in IgM level between two groups with abnormal and normal ocular conditions except for those having bulbar conjunctiva-limbal ischemia and bulbar conjunctiva-hyperemia abnormalities. There were not significant difference in IgA, IgE, and IgG levels between two groups with and without ocular problem also between study groups. IgG1 level in some ocular abnormalities were significantly lower than the healthy control groups. IgG2 level in SM-exposed participants with stromal abnormality was higher in the SM-exposed groups without this problem. IgG2 levels in the exposed group with some ocular problems were significantly increased compared with control. IgG3 level in all patients did not reveal any significant changes compared with the controls except the fundus abnormality. IgG4 level was not significantly different between two groups with normal and abnormal ocular conditions. Nonetheless, IgG4 level in the exposed participants with some ocular abnormalities significantly increased compared with the controls. Conclusion: The results showed SM exposure could alter immunoglobulins level compared with healthy controls and the changes of IgG2 and IgG1 levels were associated with some ocular problems.