Crocin as an active ingredient of saffron attenuates cognitive deficits due to intracerebroventricular injection of colchicine in the rat

Ensie Azadi Ahmadabadi | Farzane Fereidoni | Shahram Jalalzadeh | Zahra Kiasalari Reineh | Mehrdad Roghani

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137481
Date :  2019/10/30
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران


Keywords :Colchicine, Cognitive decline, Crocin, Saffron

Abstract :

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Background and Objective: Cognitive dysfunction is a typical phenotype of Alzheimers disease (AD). Crocin has shown beneficial effect in different models of cognitive decline. In this study, we evaluated whether crocin could prevent cognitive dysfunction due to intracerebroventricular injection of colchicine in the rat. Materials and Methods: Male rats (n = 32) were assigned to four experimental groups as follows: Sham, lesion (receiving intracerebroventricular colchicine bilaterally at a dose of 15 microg), and two lesion groups receiving crocin p.o. at doses of 10 or 50 mg/kg in addition to colchicine. Finally, passive avoidance and Y-maze tests were used to assess cognition. Results: Our data demonstrated that intracerebroventricular colchicine could significantly lower alternation in Ymaze and step-through latency in passive avoidance and administration of crocin to lesion group at a dose of 50 mg/kg could significantly improves performance of animals in these tasks. Conclusion: Crocin at a dose of 50 mg/kg could effectively ameliorate learning and memory decline due to intracerebroventricular injection of colchicine in the rat.