Shahed University

The effect of hydro-alcoholic extract of Mentha pulegium on pain and seizure induced by pentylenetetrazol in male mice

Mahdi Alizadeh | Fatemeh Taleahmad | Fatemeh Nabi | Fariba Ansari | Zahra Kiasalari Reineh | Mohsen Khalili

Date :  2019/10/30
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران

Keywords :pain, seizure, Ant nociceptive, Mentha pulegium, Mice

Abstract :
Background and Objective: In recent years, the use of medicinal plants has increased instead of chemical drugs due to fewer side effects and more diverse compounds. The aim of this study was to witness the analgesic and anticonvulsant effect of Puneh plant. Materials and Methods: In this study, we used 40 male mice, and the PTZ test for evaluating the anticonvulsant effects and formalin and tail immersion tests in hot water to determine the anti-nociceptive effect of the plant were used. Results: Hydro-alcoholic extracts of Pune leaf significantly decreased pain in the acute and chronic phase in the formalin test, which had the most analgesic effect in 800 mg /kg and all doses were effective in acute pain. Also, in the PTZ test, the anticonvulsant effect in doses of 200 and 600 mg /kg was shown. However, In tail immersion test, the acute pain was unaffected Conclusion: The results of this study indicated that hydro- alcoholic extract of Pune leaf can reduce chronic and acute pain and also seizure onset time.

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