Shahed University

The relationship between thyroid hormones and procalcitonin with neonatal sepsis: acase-control study in Iranin 2017

Reza Taghizadeh | Iman Ansari | Ashraf Pirasteh | Fatemeh Hajiebrahim Tehrani

Date :  2019/12/15
Publish in :    Journal of Basic and Clinical Pathophysiology

Keywords :Neonatal sepsis, Thyroid hormones, Procalcitonin, C-Reactive protein, Diagnosis

Abstract :
Background and Objective:Neonatal sepsis (NS) is a major cause of mortality and morbidity in neonates. Correct and early diagnosis of NS can prevent its complications. The aim of this study was to investigate the relationship between the levels of thyroid hormones and procalcitonin (PCT) with NS. Materials and Methods:In thiscase-controlstudy, 40 term neonates with proven NS diagnosis and 40 term neonates whose NS were rejected due to negative paraclinical findings were compared in terms of thyroid hormone levels, PCT and Creactive protein (CRP).Data were analyzed using SPSS v.17. Results:The most common clinical findingwas fever in both groups, while there was no significant difference between the two groups (P = 0.1). The results of laboratory tests showed that the CRP levels in the NSgroup were significantly higher than the control group (P = 0.03). In terms of thyroid hormones, although TSH and T4 were higher in the NSgroup, this difference was not statistically significant (P = 0.94andP = 0.22, respectively). In addition, PCT measurements and comparisons showed that this parameter was significantly higher in the NSgroup (P = 0.01).Conclusion:The results of this study demonstrated that CRP and PCT levels in NS neonates were significantly higher than non-NS neonates, while there was no significant difference in the level of thyroid hormones in the two groups. Further studies are recommended in this area