Shahed University

24th Iranian & 3rd International Congress of Physiology and Pharmacology, 30 Oct-01 Nov, 2019 Tehran, Iran The effects of swimming exercise and Nepeta menthoides on depression like behavior induced by reserpine

Batool Rahmati | Faezeh Rezaei | Maryam Malekian | Mohsen Khalili

Date :  2019/11/01
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران

Keywords :Depression, Reserpine, Swimming Exercise, Nepeta menthoides

Abstract :
Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempts to determine the effects of swimming exercise and Nepeta menthoides on reserpine induced depression in rats. Materials and Methods: Male rats (n=80) were assigned to 8 groups: 1-Saline, 2-Reserpine (0.2 mg/kg, i.p for 14days) 3-Swimmig Exercise( 30 min swimming sessions 5 days a week ) 4-Nepeta (200 mg/kg), 5- Reserpine+Nepeta, 6-Reserpine+Swimming exercise, 7-Reserpine+Nepeta+Swimming exercise, 8- Reserpine+Fluoxetine, Finally, the behavioral tests including sucrose preference, elevated plus maze and open field were performed. Results: Obtained data showed that depressed rats which were treated with Nepeta+ Exercise expressed higher preference for relative to other groups. However, if combined Nepeta+Exercise could not significantly antagonize the effect of reserpine on motor activity and time spent in the open arms of elevated plus maze, but mentioned items showed notable improvements in the Nepeta group. Conclusion: Combined treatment with Nepeta+exercise was able to alleviate anhedonia in depressed rats. Nevertheless, anxiety behaviors were not significantly affected by the mentioned treatment.

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