The effects of different doses of Nepeta menthoides in mice reserpine-induced depression

Batool Rahmati | Mohsen Naseri | Fatemeh Emadi | Masoumeh Jorjani | Sedighe Talebi

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=158380
Date :  2019/11/01
Publish in :    بيست و چهارمين کنگره بين المللي فيزيولوژي و فارماکولوژي


Keywords :Nepeta menthoides, Depression, Reserpin, Forced swimming, Tail suspension

Abstract :

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Backgroud: Nepeta Menthoides is an Iranian native plant with anti-depressant and sedative properties. This study was designed to search the effects of Nepeta menthoides aqueous extract pretreatment on reserpine induced depression Material and Methods: 64 male mice were randomly divided into 8 groups of 8 mice. Control normal saline (10 ml/kg), flouxetin (20 mg/kg), imipramine (10 mg/kg ), Reserpine (10 mg/kg normal saline), and treatment groups received different doses of the extracts (50, 100, 200, 400 mg/kg) for 7 days. In the 8th day all of the groups except control normal saline received reserpin (4 mg/kg) and were tested 24 hours later. Tests included forced swimming (FST), tail suspention (TST) and open field test (OFT). Results: reserpine enhanced immobility time (64.37±5.93) in compared to normal saline (38.25±2.59) while Nepeta pretreatment were declined immobility time in a dose dependent manner (25.75±5.90 (100 mg/kg)And 23.5±7.43(200 mg/kg). Also, Nepeta reduced immobility time dose dependently in tail suspension test p0.01. Open field test showed that none of agents did not influence total motility. Conclusion: Pretreatment with Nepeta menthoides could prevent of depression like behavior induced by reserpine better than fluoxetine and imipramine.