Shahed University

Comparison of effects of pomegranate peel and Mefenamic acid consumption on the treatment of Menorrhagia: A Triple-Blind Randomized Controlled Trial

Golamreza salsali | Fatemeh Emadi | Seyed Said Esmaili Saber | Mohammad Gholami Fesharaki | Nafiseh Zafarghandi

Date :  2019/12/02
Publish in :    Medical Science

Keywords :Menorrhagia, Mefenamic acid, Pomegranate peel, Traditional Persian medicine

Abstract :
Background: Menorrhagia is a type of menstrual disorder and a major health problem for many women. The consumption of pomegranate peel is a way to treat menorrhagia in the Traditional Persian Medicine (TPM). Objective: The present study aimed to compare the impact of two oral capsules of pomegranate peel extract and mefenamic acid on the treatment of Menorrhagia. Method: In the present triple-blind randomized controlled trial on 56 women aged 20-50 years with menorrhagia (intervention group: n=28, control group: n=28), the intervention group received 250 mg capsules of pomegranate peel extract; and the control group received 250 mg capsules of mefenamic acid in 7 days of menstruation three times a day for 3 months. Pictorial Blood Loss Assessment Chart (PBAC) scores and amount of Blood hemoglobin (Hb) and scores of Menorrhea Questionnaire (MQ) were utilized to evaluate the amount and duration of bleeding. Results: PBAC scores significantly decreased from 352.07 (33.26) to 166.85 (27.42) (p 0.001) in the pomegranate group and from 303.18 (24.84) to 171.03 (27.3) in the mefenamic acid group, but the difference was not significant between two groups. Furthermore, a significant increase was seen in scores of MQ and amount of Hb in both groups after the treatment (p 0.05). However, no significant difference was found between both groups. Conclusion: The pomegranate peel extract reduces bleeding, improves quality of life and increases the blood Hb in women with menorrhagia. Accordingly, it can be used in menorrhagia.