Mechanisms underlying quercetin-induced vasorelaxation in aorta of subchronic diabetic rats: an in vitro study

Mehrdad Roghani | Tourandokht Baluchnejadmojarad | Mohammadreza Vaezmahdavi | Farshad Roghani Dehkordi

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=84816
Date :  2004/12/08
Publish in :    Vascular Pharmacology
DOI :  https://doi.org/10.1016/j.vph.2004.12.001
Link :  https://www.ncbi.nlm.nih.gov/pubmed/15664885
Keywords :Mechanisms, aorta, subchronic, diabetic

Abstract :

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Abstract In this study, the mechanisms involved in vasorelaxant effect of the flavonoid quercetin was investigated in isolated aortic rings from streptozotocin (STZ)-diabetic rats. After 4 weeks, addition of quercetin (0.1 AM–1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings in both control and diabetic groups with a significant inter-group difference of Pb0.01. Furthermore, both nitro-l-arginine-methyl ester (l-NAME, 100 AM) and indomethacin (10 AM) markedly attenuated the vasorelaxant responses following quercetin application. Meanwhile, endothelium removal significantly attenuated the quercetin-induced vasorelaxation. It is concluded that the quercetin can relax the preconstricted rings of aorta in subchronic STZ-diabetic rats through nitric oxide- and - prostaglandin-mediated pathways, which themselves could be considered as endothelium-dependent. D 2004 Elsevier Inc. All rights reserved.