Comparison of Immunomodulatory Effects of Some Allium species from Iran on Cytokine Generation

Hosseinpur Z | Radjabian T | Ghazanfari T | Naghizadeh Mm

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=106102
Date :  2018/04/28
Publish in :    14th Internatinal Congress of Immunology

Link :  http://icia.ir/
Keywords :Allium species, Bulb extract, Cytokines, IFN-?, IL-4, IL-17

Abstract :

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Background: The literature review has demonstrated that extract of Allium sativum (garlic) modulates the cytokines release patterns in lymphocytes. But there are unveiled data about immunomodulatory potentials of the other Allium species. So, in the present research, the effects of extracts from some wild grown Allium species of Iran on IFN-γ, IL-4 and IL-17 production were evaluated. Methods: The bulbs of some Allium species were collected from their natural localities and the aqueous extracts of them were prepared. Lymphocytes were isolated from BALB/c mice and were incubated with various concentrations of the bulb extracts. Finally, the levels of IFN-γ, IL-4 and IL-17 were measured. Results: Bulb extracts of A. sativum had stimulatory effects on production of IFN-γ and IL-17, so the extracts could probably switch immune responses towards Th1 and Th17 cells pattern. Bulb extracts of A. asarense increased secretion values of IL-4 from lymphocytes. Whilst, bulb extracts of A. sativum decreased the amounts of IL-4, especially in the higher concentrations. Therefore, A. asarense and A. sativum may be significantly acted as a stimulator and inhibitor of Th2 cells, respectively, in some concentrations. On the other hand, bulb extract of A. jesdianum significantly decreased the amounts of IL-4 and IL-17, especially in the higher concentrations. Hence it seems that this species reduced the response of Th2 and Th17 cells. Conclusion: In general, bulb extracts of the Allium species had immunomodulatory effects on the lymphocyte cytokines levels, which are involved in immune related-diseases, and these species may be considered for treatment studies.

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