A Comparative Study on the Effects of Allium asarense and Allium sativum Extracts on Lymphocytes

Hatami H | Tayebeh Radjabian | Hosseinpur Z | Ghazanfari T | Naghizadeh Mm

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=106104
Date :  2018/04/28
Publish in :    14th Internatinal Congress of Immunology

Link :  http://icia.ir/
Keywords : Allium species, IFN-?, IL-4, IL-17

Abstract :

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Background: Garlic (Allium sativum) is used as an effective herbal medicine for the treatment of the autoimmune diseases and cancers. Although there are many studies on two Allium species (Allium sativum and Allium cepa), there is no scientific report on the other Allium species. The aim of this study was to compare the in vitro effects of aqueous bulb extracts of wild A. asarense and cultivated A. sativum on lymphocytes. Methods: Lymphocytes were isolated from BALB/c mice and were incubated with various concentrations of the aqueous bulb extracts of the studied Allium species. Finally, the cytokines concentration and lymphocyte viability were evaluated and compared. Results: The results did not show significant increases in the viability of lymphocytes after incubation with A. asarense bulb extract, however significant increases were observed in the viability of lymphocytes after treatment with lower concentration (≤0.05mg/ml) of A. sativum extract. Although no significant changes were found in IL-17 and IL-4 concentration after treatment with two Allium extracts, IFN-γ concentration was decreased by A.asarense extract and was increased by A. sativum extract. Conclusion: It suggests that similar to A. sativum, the extract of A. asarense may be regulate the IFN-γ levels.

http://icia.ir/