Frequency Distribution, Genotypes and the most Prevalent Sequence Types of New Delhi Metallo-beta-lactamase-Producing Escherichia coli among Clinical Isolates around the World

Parviz Owlia

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=116724
Date :  2019/06/08
Publish in :    Journal of Global Antimicrobial Resistance
DOI :  https://doi.org/https://doi.org/10.1016/j.jgar.2019.06.008
Link :  https://www.ncbi.nlm.nih.gov/pubmed/31212107
Keywords :Genotypes, Escherichia, Isolates, World

Abstract :

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Background and Aim: New Delhi Metallo-beta-lactamase (NDM)-producing Escherichia coli (E. coli) is allegedly perceived as one of the primary multidrugresistant bacteria causing infections in hospitals and clinics. In this paper we present the frequency distribution, genotypes and the most prevalent sequence types (STs) of NDM-producing E. coli among clinical isolates worldwide. Methods: Several international databases including Medline, Embase, Scopus and Web of sciences were searched from 2008 to 2018 to discern the studies that addressed the prevalence of NDM-producing E. coli around the world. Results: Of the 974 records identified from the databases, 110 studies fulfilled the eligibility criteria. The analyses demonstrated that the prevalence of NDMproducing E. coli were 83.0, 13.0, 1.0, 1.0 and 2.0 in Asia, Europe, America, Africa and Oceania continents, respectively. According to our results, the most common reported STs among NDM- producing E. coli were ST101, ST167, ST131, ST405, ST410 and ST648. Conclusions: Distribution of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups such as ST101 and ST167 are one of the main causes of E. coli infection in different countries.