The effect of safranal on prevention of learning and memory deficits following intracerebroventricular injection of colchicine in the rat

Farzane Fereidooni | Ensie Azadi Ahmadabadi | Shahram Jalalzadeh | Zahra Kiasalari Reineh | Mehrdad Roghani

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137486
Date :  2019/10/30
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران


Keywords :Safranal, Colchicine, Cognitive decline

Abstract :

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Background and Objective: Cognitive decline is associated with Alzheimers disease that is considered a chronic and progressive syndrome that finally leads to irreversible loss of neurons. In this study, we assessed whether safranal has a beneficial effect on cognitive function following intracerebroventricular injection of colchicine in the rat. Materials and Methods: 32 male rats were randomly divided into four groups as follows: Sham, lesion (receiving intracerebroventricular colchicine bilaterally at a dose of 15 microg), and two lesion groups receiving oral safranal at doses of 10 or 50 mg/kg in addition to colchicine. Finally, passive avoidance and Y-maze tests were used to assess learning and memory. Results: The results showed that intracerebroventricular colchicine significantly reduces alternation and stepthrough latency in behavioral tests and treatment of lesion group with safranal at a dose of 50 mg/kg significantly improves these parameters. Conclusion: Taken together, safranal could prevent learning and memory deficits following intracerebroventricular injection of colchicine in the rat.