The effect of nobiletin on behavioral function in plus elevated and forced swim tests in amyloid beta-induced model of Alzheimers disease in the rat

Marzieh Fakour | Zahra Kiasalari Reineh | Reihane Ghasemi | Maryam Khorasani | Sedigheh Keshtkar | Mehrdad Roghani

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137488
Date :  2019/10/30
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران


Keywords :Alzheimers disease, Amyloid beta, anxiety and depression, Nobiletin, Elevated plus maze, Forced swimming test

Abstract :

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Background and Objective: Alzheimers disease (AD) is the most common form of dementia that is considered a chronic and progressive syndrome, that leads to the irreversible loss of neurons, particularly in the cortex and hippocampus. In this study we considered whether nobiletin has any effect on behavioral function in plus elevated and forced swim tests in amyloid beta-induced model of Alzheimers disease in the rat. Materials and Methods: 32 male rats were randomly divided into four groups as follows: group A (Sham), group B (sham+nobiletin), which were administrated nobiletin (10 mg/kg) daily one hour after surgery for one week via gavage, group C (Aβ): which amyloid β1-40 (2 nanomol/2 μl) was injected into hippocampal region (CA1) bilaterally, and group D (Aβ + nobiletin), which were administrated nobiletin (10 mg/kg). Furthermore, two behavioral tests including elevated plus maze and forced swimming tests were used to assess animal performance. Results: The results showed that group C has a significant increase regarding anxiety, Moreover, Aβ group which was treated with nobiletin exhibited significant reduction of the aforementioned parameters. Meanwhile, no significant changes were observed in nobiletin-treated sham group. Conclusion: Taken together, these findings suggest that nobiletin could reduce anxiety in amyloid beta-induced model of AD in the rat with no significant effect on depression.