24th Iranian & 3rd International Congress of Physiology and Pharmacology, 30 Oct-01 Nov, 2019 Tehran, Iran The effects of mental exercise and Nepeta menthoides on depression like behavior induced by reserpine

Mohsen Khalili | Maryam Malekian | Batool Rahmati | Faezeh Rezaei

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137779
Date :  2019/11/01
Publish in :    24 امين کنگره ملي و سومين کنگره بين المللي فيزيولوژي و فارماکولوژي ايران


Keywords :Depression, Reserpine, Mental Exercise, Nepeta menthoides

Abstract :

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Background and Objective: Many studies demonstrate that cognitive empowerment reduces the risk of depression.Anti-depressant properties of Nepeta menthoides as an herbal medicine has also been reported. This study aims to determine the effects of mental exercise and Nepeta menthoides on reserpine induced depression in rats. Materials and Methods: Male rats were divided into 8 groups: 1-Saline, 2-Reserpine,3-Reserpine + Fluoxetine,4-Nepeta,5-Nepeta +Reserpine, 6-Mental exercise,7-Mental exercise+ Reserpine, 8-Mental exercise + Nepeta +Reserpine. Reserpine was administered at a dose of 0.2 mg/kg for 14 days.At the same time, the animals received Nepeta at the dose of 200 mg/kg and radial maze training. Then the results were assessed through forced swimming test (FST), sucrose preference, elevated plus maze and open field tests. Results: Reserpine enhanced immobility and decreased active swimming time significantly, in the FST, while mental exercise combined with Nepeta were able to antagonize the effect of reserpine. Reserpine also lowered sucrose preference ratio which were recovered in mental exercise, Nepeta and combined treatment groups. Time spent and of entrance in to the open arms have been increased by Nepeta and mental exercise relative to reserpine. Decreased locomotor activity due to reserpine had been improved in mental exercise and Nepeta groups.The mental exercise was also found to increase number of rearing as exploratory behavior. Conclusion: Nepeta menthoides and mental exercise alleviated the depression symptoms caused by Reserpine.