Presence of CC Genotype for rs17773430 Could Affect the Percentage of Excess Weight Loss 1 Year After Bariatric Surgery: Tehran Obesity Treatment Study (TOTS)

Niloufar Javanrouh | Alireza Khlaj | Kamran Guity | Bahareh Sedaghati-khayat | Majid Valizadeh | Maryam Barzin | Maryam S. Daneshpour

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=137920
Date :  2019/10/22
Publish in :    Obesity Surgery: The Journal of Metabolic Surgery and Allied Care
DOI :  https://doi.org/10.1007/s11695-019-04211-w
Link :  http://dx.doi.org/10.1007/s11695-019-04211-w
Keywords : Associationanalysis .MC4Rgene .Bariatricsurgery .Cohortstudy .Obesity .Kernelmachine

Abstract :

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Background Morbidobesity could lastfor alongperiodoflifeand increasethe riskofmorbidityas well aspremature mortality. Althoughbariatricsurgerybenefitspatientsbyquickweightloss,notallbariatricpatientslosethesamepercentageofweightafter a long time from surgery, which may be the result of diet, physical activity, and genetic components. Objectives Inthisstudy,weevaluatedtheassociationbetweentheMC4Rgeneandbothexcessweightlosspercentage(EWL) and excess BMI loss percentage (EBMIL) in a cohort of bariatric surgery patients after 6 and 12 months from surgery. Methods A total of 424 bariatric surgery patients who had participated in the Tehran Obesity Treatment Study and had weight measurements after 6 and 12 months from surgery were included in the study. Four SNPs in the MC4R gene were selected for evaluating the associations. Results Wefoundthatrs17773430hadasignificanteffectonbothEWLandEBMIL,especiallyafter 12monthsofbariatric surgery. Furthermore, three other SNPs, rs17782313, rs476828, and rs11152213, did not show any significant association with EWL and EBMIL. Conclusion This study was the first to report on the association of rs17773430 with both EWL and EBMIL in a cohort of patientsafterbariatricsurgery.Wefoundthatweightlossaftersurgeryisinfluencedbygeneticfactors,andthereweresignificant differencesbetweenthedistributionofEWLandEBMILinmorbidobesebariatricpatientswhohavetwominorallelesofthe rs17773430 and other SNPs.