The combined effect of high-intensity interval training and intermittent fasting on lipid profile and peroxidation in Wistar rats under high-fat diet

Ali Samadi | Behzad Bazgir | Bahman Abbasi

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=147964
Date :  2020/03/19
Publish in :    Sport Sciences for Health
DOI :  https://doi.org/https://doi.org/10.1007/s11332-020-00637-3
Link :  https://link.springer.com/article/10.1007/s11332-020-00637-3citeas
Keywords :High-Fat Diet, Lipid Profile, Lipid Peroxidation, High-Intensity Interval Training, Intermittent Fasting

Abstract :

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Purpose: High-fat diets are considered as the main risk factor for the development of dyslipidemia and lipid peroxidation, which in turn result in serious health problems such as cardiovascular disease, type 2 diabetes and some forms of cancers. So, the purpose of this study was to investigate the combined effect of high-intensity interval training (HIIT) and intermittent fasting (IF) on lipid profile and peroxidation in Wistar rats under high-fat diet. Methods: A total of 28 male Wistar rats went through a high-fat diet for 12 weeks. Then, they were randomly divided into four groups: (1) HIIT (3 d/w-1 for 6 weeks), (2) IF (3 d/w-1 for 6 weeks), (3) combined HIIT and IF (received both intervention for 6 weeks), and (4) control (CON). All groups were under high-fat diet till the end of the study. Results: According to the results, LDL levels significantly decreased in HIIT group compared to CON group. The IF and HIIT+IF groups a non-significant increase in HDL was observed compared to CON group. In HIIT+IF and HIIT groups, LDL/ HDL ratio decreased significantly compared to the CON group (P0.05). Moreover, IF significantly decreased TG compared to both HIIT and HIIT+IF groups. None of the interventions were able to decrease serum MDA levels in comparison with CON group. Conclusion: Our results suggest that in subjects under high-fat diet, both HIIT and IF may help improve lipid profile, but their combination may not have any synergistic effects. Also, IF and HIIT+IF may increase lipid peroxidation in subjects under high-fat diet.