Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association with Clinical Laboratory Routine Tests

Abdolrahman Rostamian | Jalil Arabkheradmand | Maryam Edalatifard | Sara Ghaffarpour | Mohammad Reza Salehi | Seyed Reza Raeeskarami | Maedeh Mahmoodi Aliabadi | Maryam Rajabnia Chenary | Ensie Sadat Mirsharif | Davoud Jamali | Mohammad Reza Sattarian | Reza Najafizadeh | Sajjad Hosseinieselki Sari | Samira Jafarpour | Elham Nezhadseifi | Shafieh Movasseghi | Elahe Baharvand | Saba Beiranvand | Azin Roomi | Tooba Ghazanfari

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=158813
Date :  2020/10/01
Publish in :    Immunoregulation
DOI :  https://doi.org/10.32598/IMMUNOREGULATION.3.1.4
Link :  http://dx.doi.org/10.32598/IMMUNOREGULATION.3.1.4
Keywords : interleukin (IL)-6 , COVID-19

Abstract :

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Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients. Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests. Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P0.001). The IL-6 level was approximately 10-fold of the normal range in 22.9 of the patients. Also, more than 56.1 of them signify IL-6 over 3-fold of the normal range. IL-6