Efficacy of Plantago major seed in management of ulcerative colitis symptoms: A randomized, placebo controlled, clinical trial

Atiyeh Baghizadeh | Ali Jafari Heidarloo | Fatemeh Emadi | Jale Aliasl | Ali Davati

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=159318
Date :  2021/08/15
Publish in :    Complementary Therapies in Clinical Practices
DOI :  https://doi.org/10.1016/j.ctcp.2021.101444
Link :  http://dx.doi.org/10.1016/j.ctcp.2021.101444
Keywords :Inflammatory bowel disease Ulcerative colitis Persian medicine Plantago major

Abstract :

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Objective: Evaluation of the effect of Plantago major (P. major) seed on ulcerative colitis (UC) symptoms. Methods: In this randomized double-blind clinical trial, 61 subjects received 3600 mg/day roasted P. major seed in intervention group (n = 31) and roasted wheat flour in control group (n = 30), for 8 weeks, as a complementary to standard medications. Variables were assessed using the Lichtiger Colitis Activity Index (LCAI) at baseline, week 4, and week 8. Results: 51 patients completed the trial (n = 28 in Plantago and n = 23 in placebo groups). Abdominal tenderness (p = 0.011), gastroesophageal reflux and gastric pain (p = 0.049 for both), were significantly less severe in P. major group. Visible blood in stool (p = 0.001), distension (p = 0.001), and anal pain (p = 0.051), decreased significantly in P. major group, although no significant difference was observed between the two groups: (p = 0.224), (p = 0.283), and (p = 0.455) respectively. Conclusion: P. major seems to be effective in complementary management of UC.