The Association of ABO and RhD Blood Group with Disease Severity in COVID-19

Mohammad Mehdi Attarpour Yazdi

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=169875
Date :  2020/11/10
Publish in :    14th professor Alborzi International Clinical Microbiology


Keywords :COVID?19, ABO and RhD Blood Group, Disease Severity, SARS?CoV?2

Abstract :

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Introduction and Objectives: The rapid global spread of the Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has strained healthcare and testing resources, making the identification and prioritization of individuals most at-risk a critical challenge. Recent evidence suggests ABO and RhD blood group may affect risk of severe COVID-19. Materials and Methods: The methodology used in this research is a semi-experimental one and a retrospective cohort analysis. The research was conducted on 253 COVID-19 patients that was tested by SARS-CoV-2- real-time- polymerase chain reaction assay (SARS-CoV-2- RT-PCR) between 3 May 2020 and 29 September 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on Disease Severity in Tehran (Iran). Results: The frequency distribution tables, diagrams, chi-square, t-test and one way anova were used to analyze the data. Significant statistical relationship was observed between ABO and RhD blood group and Disease Severity (P 0.05). The results showed that COVID-19 patients with blood types A and AB were more prone to dysfunction or organ failure than those with blood groups O and B (especially Rh negative). In addition, people with blood types A and AB experienced more severe symptoms of COVID-19 than others. As a result, they were hospitalized longer in the intensive care unit. Conclusion: We found that ABO and RhD blood group may play a role in Disease Severity in COVID-19. However, additional research is needed to better understand why and what it means for patients.