Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats

Soheila Pourkhodadad | Masoud Alirezaei | Mehrnoush Moghaddasi | Hassan Ahmadvand | Manizheh Karami | Bahram Delfan | Zahra Khanipour

---

URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=31656
Date :  2016/02/22
Publish in :     Journal of Physiological Sciences
DOI :  https://doi.org/10.1007/s12576-016-0437-4
Link :  http://www.springer.com/
Keywords :Oleuropein  Colchicine  Alzheimer’s disease  Oxidative stress  Hippocampus

Abstract :

---

Abstract Alzheimer’s disease is a progressive neurodegenerative disorder with decline in memory. The role of oxidative stress is well known in the pathogenesis of the disease. The purpose of this study was to evaluate pretreatment effects of oleuropein on oxidative status and cognitive dysfunction induced by colchicine in the hippocampal CA1 area. Male Wistar rats were pretreated orally once daily for 10 days with oleuropein at doses of 10, 15 and 20 mg/kg. Thereafter, colchicine (15 lg/rat) was administered into the CA1 area of the hippocampus to induce cognitive dysfunction. The Morris water maze was used to assess learning and memory. Biochemical parameters such as glutathione peroxidase and catalase activities, nitric oxide and malondialdehyde concentrations were measured to evaluate the antioxidant status in the rat hippocampus. Our results indicated that colchicine significantly impaired spatial memory and induced oxidative stress; in contrast, oleuropein pretreatment significantly improved learning and memory retention, and attenuated the oxidative damage. The results clearly indicate that oleuropein has neuroprotective effects against colchicineinduced cognitive dysfunction and oxidative damage in rats.