Synthesis with Improved Yield and Study on the Analgesic Effect of 2-Hydroxyphencyclidine

Ahmadi Abbas | Shafiezadeh Mahshid | Fathollahi Yaghoob | Darvich Mohammad Raouf | Mahmoudi Ali | Bahmani Manouchehr | Rahmati Batol

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URL :   http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=42578
Date :  2005/02/10
Publish in :    Arzneimittel-Forschung/Drug Research
DOI :  https://doi.org/10.1055/s-0031-1296840

Keywords :Synthesis, improved

Abstract :

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Phencyclidine (1-(1-phenylcyclohexyl)pi-peridine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a hydroxyl group has been added to the position 2 of the cyclohexane ring of PCP, this compound would be more hydrophilic than PCP. This compound was synthesized using a different and improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-hydroxy-phencyclidine can increase tail-flick latencies as compared to the control group and indicate that the maximum analgesic effect of this compound occurs 2–5 min after its injection while the effect of ketamine is observed 10–25 min after injection