Shahed University
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DROSERA SPATULATA
Ali Hakakian | Tayebeh Radjabian | Majid Hassanpour-Ezatti | Mehdi Zarrei | Amin Davari
URL :
http://research.shahed.ac.ir/WSR/WebPages/Report/PaperView.aspx?PaperID=64463
Date :
2017/11/16
Publish in :
International Journal of Pharmaceutical Sciences and Research
Link :
http://ijpsr.com/articles/
Keywords :
Drosera spatulata, Analgesic, Anti-inflammatory
Abstract :
ABSTRACT: The aim of the present study is to investigate and evaluate nalgesic and anti-inflammatory potential of aqueous and methanolic extracts of Drosera spatulata using different models in rats. The aqueous and methanolic extracts of D. spatulata (at the doses of 3, 4, 5, 8 and 10 mg/Kg body weight) investigated for anti-inflammatory and analgesic activities using various experimental models. Analgesic activity was evaluated using formalin induced paw licking models in rats. Antiinflammatory activity was evaluated using measurement of paw edema volume model in rats. Our results showed that both extracts caused a significant (P 0.05) dose-dependent reduction of inflammation an pains induced by agent used. These results provide support for the use of aqueous and methanolic extracts of Drosera spatulata in relieving inflammatory, pain and insight into the development of new agents for treating inflammatory and pain diseases but further studies are needed to elucidate the mechanism (s) of action and phytochemical constituents of the plant.
Authors' Home page
Tayebeh Radjabian
Majid Hassanpour-Ezatti